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With the financial and legal autonomy, Calmette Hospital is headed by Professor KONG Sonya, Director General.

The Director General is assisted by one Deputy Director General and a management team, a board of Directors, as well as a Medical Commission and a Hygiene and Security Committee.

The general policy of the institution is determined by the Board of Directors, made up of representatives of the Ministry of Health, Ministry of Economy and Finance, the Council of Ministers, the Municipality of Phnom Penh, the University of Health Sciences and staff of the hospital.